C:\Program Files (x86)\
Modding the Wineskin version can be done by firstly installing the Windows version in a virtual machine, patching it and installing all desired modifications and then replacing the System Shock 2 installation within the Wineskin version with the custom version. If you are using the Steam version it may be necessary to deactivate Steam's "Keep up to date" function for this to work.
System Shock 2\cam_ext.cfg
Disable vsync in the video card control panel.
Note: If the above does not fix the issue, you may try scaling the ui to arbitrary resolutions by re-commenting out the above line (add back in the semicolon), uncommenting the line ;d3d_disp_scaled_2d_overlay 640 480 and adjusting the 640 and the 480 to your desired resolution. However, this may cause the ui to become blurry/pixelated, so try the initial fix first.
;d3d_disp_scaled_2d_overlay 640 480
See High frame rate.