Topic on Talk:Wine
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https://www.winehq.org/pipermail/wine-users/2008-May/035424.html
https://bugs.winehq.org/show_bug.cgi?id=11764
This (together with lack of dx10 support) are the 2 bigger problems imo EDIT2017: seems like the only important blocker these days is supporting PUBG anticheat /s