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Apply the Fable: The Lost Chapters intro skip.
There is a bug with many ATI/AMD drivers that causes the game to crash as soon as you try to launch a new game or load an old one. To fix this, set all of the "Shadow" settings to the minimum, then start a new game. Once you are in the game, you can change the setting to as high as you want. After you have done this once, you should be able to load into your new game with no problem. Just make sure you don't change any graphical settings in the main menu.