Occasionally with certain USB controllers or devices, the mouse will fling to the far edges of the screen, preventing proper aiming. To solve this, try:
%LOCALAPPDATA%\EA Games\Dead Space 2
Rollback to older driver version (Such as Catalyst 12.6)
Occasionally, when starting the game on a newer system, the main window will minimize itself and will not let the user restore it. To solve this, do the following:
Window.Fullscreen = true
Window.Height = 1200
Window.Width = 1920
where Window.Height is your desired height and Window.Width is your desired width.