A controller will bypass the mouse acceleration problem.
Using Dxtory to limit frame rate (for example, to 60 FPS) will limit mouse acceleration.
Prototype on Nvidia graphics card.
Prototype on AMD/ATI graphics card.
Ensure Data Execution Prevention (DEP) is set to the default (Windows programs and services only).
Alt+tabbing in and out of the game appears to release 500-600mb of RAM, delaying the onset of a memory leak crash temporarily.
Unplug the device(s) before starting the game, then plug them back in.
HID-compliant consumer control device
Evolve by consuming/finding collectibles to proceed with missions.